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There are several matches for '5-hydroxymethyluracil DNA glycosylase'.
Please select one from the list below and press Continue to proceed.
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723 matches
showing page 1 of 37
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organism
protein
1)
Homo sapiens
TDG - G/T mismatch-specific thymine
DNA
glycosylase
;
DNA
glycosylase
that plays a key role in active
DNA
demethylation: specifically recognizes and binds
5
-formylcytosine (5fC) and
5
-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove
5
-hydroxymethylcytosine (5hmC). According to an alternative model, involved in
DNA
demethylation by mediating
DNA
glycolase activity toward
5
-
hydroxymethyluracil
(5hmU) produced by deamination of 5hmC. Also involved in
DNA
repair by acting as a thym [...]
[a.k.a. ENSP00000445899, TDG-209, XP_005269182.1]
2)
Homo sapiens
SMUG1 - Single-strand selective monofunctional uracil
DNA
glycosylase
; Recognizes base lesions in the genome and initiates base excision
DNA
repair. Acts as a monofunctional
DNA
glycosylase
specific for uracil (U) residues in
DNA
with a preference for single-stranded
DNA
substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U),
5
-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [
5
-hydroxyuracil (hoU) and
5
-
hydroxymethyluracil
(hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (
5
-hydroxycytosine and
5
- formy [...]
[a.k.a. SMUG1-204, XP_016874609.1, NM_001351262]
3)
Mus musculus
Tdg - G/T mismatch-specific thymine
DNA
glycosylase
;
DNA
glycosylase
that plays a key role in active
DNA
demethylation: specifically recognizes and binds
5
-formylcytosine (5fC) and
5
-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove
5
- hydroxymethylcytosine (5hmC). According to an alternative model, involved in
DNA
demethylation by mediating
DNA
glycolase activity toward
5
-
hydroxymethyluracil
(5hmU) produced by deamination of 5hmC. Also involved in
DNA
repair by acting as a thy [...]
[a.k.a. XM_006513577, C-JUN leucine zipper interactive protein JZA-3, ENSMUST00000145370]
4)
Mus musculus
Smug1 - Single-strand selective monofunctional uracil
DNA
glycosylase
; Recognizes base lesions in the genome and initiates base excision
DNA
repair. Acts as a monofunctional
DNA
glycosylase
specific for uracil (U) residues in
DNA
with a preference for single-stranded
DNA
substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U),
5
-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [
5
-hydroxyuracil (hoU) and
5
-
hydroxymethyluracil
(hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (
5
-hydroxycytosine and
5
- formy [...]
[a.k.a. XP_011244033, EC 3.2.2.-, 3.2.2.-]
5)
Escherichia coli K12
mutM - Formamidopyrimidine/5-formyluracil/
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and its derivatives such as guanidinohydantoin:C and spiroiminodihydantoin:C, however it also acts on thymine glycol:G,
5
,6-dihydrouracil:G and
5
-hydroxyuracil:G. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-de [...]
[a.k.a. b3635, AAC76659.1, EG10329]
6)
Acinetobacter baumannii BJAB07104
AGQ15534.1 - Formamidopyrimidine-DNA glycosylase; COG:COG0266.
[a.k.a. BJAB07104_03166, DNA-formamidopyrimidine glycosylase, AGQ15534,
5-hydroxymethyluracil DNA glycosylase
]
7)
Acinetobacter brisouii
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. KJV38458.1, VH98_09490, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
8)
Acinetobacter equi
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. AOY20_07380, ALH95372.1, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
9)
Acinetobacter gyllenbergii
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. NG55_16130, OBY73333.1, NZ_KV575267.1,
5-hydroxymethyluracil DNA glycosylase
]
10)
Acinetobacter harbinensis
KWQ05820.1 -
5
-
hydroxymethyluracil
DNA
glycosylase
; Derived by automated computational analysis using gene prediction method: Protein Homology.
[a.k.a. SE27_11490, KWQ05820,
5-hydroxymethyluracil DNA glycosylase
]
11)
Acinetobacter johnsonii
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. ALV72025.1, RZ95_03330, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
12)
Acinetobacter nosocomialis
mutM - DNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
[a.k.a. B7L44_04125, ARG15861.1, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
13)
Acinetobacter sp. SFB
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. AY606_14905, OAL80882.1, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
14)
Acinetobacter sp. SFD
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. AY605_13090, OAL82230.1, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
15)
Acinetobacter sp. TTH04
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. AMQ28_04750, ALD01732.1, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
16)
Actibacterium mucosum
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. KAJ57361.1, ACMU_02335, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
17)
Aerococcus viridans
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. AWM76_03150, AMC00629.1, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
18)
Afipia massiliensis
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. YH63_12345, KKY11245.1, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
19)
Afipia sp. P5210
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. ETR77662.1, X566_08425, Fapy-DNA glycosylase,
5-hydroxymethyluracil DNA glycosylase
]
20)
Afipia sp. Root123D2
mutM -
5
-
hydroxymethyluracil
DNA
glycosylase
; Involved in base excision repair of
DNA
damaged by oxidation or by mutagenic agents. Acts as
DNA
glycosylase
that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the
DNA
strand. Cleaves the
DNA
backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and
5
'-phosphates.
[a.k.a. KQW19360.1, ASC80_18355, KQW19360,
5-hydroxymethyluracil DNA glycosylase
]
723 matches
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